Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells

Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells

Metabolic reprogramming and its molecular underpinnings are critical to unravel the duality of cancer cell function and chemo-resistance. Here, we use a constraints-based integrated approach to delineate the interplay between metabolism and epigenetics, hardwired in the genome, to shape temozolomide...

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Bibliographic Details
Main Authors: Ghanate, A.D (Author), Immanuel, S.R.C (Author), Panchagnula, V. (Author), Parmar, D.S (Author), Raghunathan, A. (Author), Uthup, R. (Author), Yadav, R. (Author)
Format: Article
Language:English
Published: Nature Research 2021
Subjects:
alkylating agent
Antineoplastic Agents, Alkylating
apoptosis
Apoptosis
Cell Line, Tumor
cell proliferation
Cell Proliferation
cell survival
Cell Survival
drug effect
drug resistance
Drug Resistance, Neoplasm
gene expression
Gene Expression
gene expression regulation
Gene Expression Regulation, Neoplastic
genetic procedures
Genetic Techniques
genetics
Genetics
glioblastoma
Glioblastoma
human
Humans
metabolism
metabolomics
Metabolomics
physiology
procedures
signal transduction
Signal Transduction
systems biology
Systems Biology
temozolomide
Temozolomide
tumor cell line
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