Multi-omic regulatory networks capture downstream effects of kinase inhibition in Mycobacterium tuberculosis

Multi-omic regulatory networks capture downstream effects of kinase inhibition in Mycobacterium tuberculosis

The ability of Mycobacterium tuberculosis (Mtb) to adapt to diverse stresses in its host environment is crucial for pathogenesis. Two essential Mtb serine/threonine protein kinases, PknA and PknB, regulate cell growth in response to environmental stimuli, but little is known about their downstream e...

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Bibliographic Details
Main Authors: Carette, X. (Author), Helmel, M. (Author), Husson, R.N (Author), Platig, J. (Author), Quackenbush, J. (Author), Steen, H. (Author), Young, A.T (Author)
Format: Article
Language:English
Published: Nature Research 2021
Subjects:
bacterial protein
Bacterial Proteins
cell wall
Cell Wall
drug effect
gene expression
Gene Expression
gene expression regulation
Gene Expression Regulation, Bacterial
genetics
growth, development and aging
metabolism
Mycobacterium tuberculosis
phosphorylation
Phosphorylation
PknA protein, Mycobacterium tuberculosis
PknB protein, Mycobacterium tuberculosis
protein kinase inhibitor
Protein Kinase Inhibitors
protein serine threonine kinase
Protein-Serine-Threonine Kinases
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