High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce. However, most ToxCast screening assays have evaluated individual biological targets in cancer cell...

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Bibliographic Details
Main Authors: Baker, N.C (Author), Bonzo, J.A (Author), Ferguson, S.S (Author), Franzosa, J.A (Author), Hester, S. (Author), Houck, K.A (Author), Hurban, P. (Author), Jack, J. (Author), Kothiya, P. (Author), Shah, I. (Author), Siferd, S. (Author), Wambaugh, J.F (Author), Witek, R.P (Author)
Format: Article
Language:English
Published: Nature Research 2021
Subjects:
Bayes theorem
Bayes Theorem
cell culture technique
Cell Culture Techniques
cell line
Cell Line
cytology
drug effect
genetics
Hepatocytes
high throughput screening
High-Throughput Screening Assays
human
Humans
liver
Liver
liver cell
molecular library
procedures
Small Molecule Libraries
toxicogenetics
Toxicogenetics
transcription factor
Transcription Factors
transcriptome
Transcriptome
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