Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis
Different cancer cell lines can have varying responses to the same perturbations or stressful conditions. Cancer cells that have DNA damage checkpoint-related mutations are often more sensitive to gene perturbations including altered Plk1 and p53 activities than cancer cells without these mutations....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Research
2021
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |