CD24, CD44 and EpCAM enrich for tumour-initiating cells in a newly established patient-derived xenograft of nasopharyngeal carcinoma

CD24, CD44 and EpCAM enrich for tumour-initiating cells in a newly established patient-derived xenograft of nasopharyngeal carcinoma

Subpopulations of nasopharyngeal carcinoma (NPC) contain cells with differential tumourigenic properties. Our study evaluates the tumourigenic potential of CD24, CD44, EpCAM and combination of EpCAM/CD44 cells in NPC. CD44br and EpCAMbr cells enriched for higher S-phase cell content, faster-growing...

Full description

Bibliographic Details
Main Authors: Abdul Aziz, N. (Author), Abdul Razak, F.R (Author), Ahmad, M. (Author), Chin, Y.M (Author), Chu, T.L (Author), Hoe, S.L.L (Author), Khoo, A.S.-B (Author), Koay, C.E (Author), Liew, K. (Author), Lo, K.-W (Author), Mohamed Shahrehan, N.A (Author), Mohd Kornain, N.K (Author), Ng, C.-C (Author), Peh, S.-C (Author), Tan, L.P (Author), Teow, S.-Y (Author)
Format: Article
Language:English
Published: Nature Publishing Group 2017
Subjects:
animal
Animals
Biomarkers, Tumor
cancer stem cell
CD24 antigen
CD24 Antigen
CD44 protein, human
Cell Line, Tumor
EPCAM protein, human
epithelial cell adhesion molecule
Epithelial Cell Adhesion Molecule
female
Female
genetics
human
Humans
Hyaluronan Receptors
hyaluronic acid binding protein
knockout mouse
metabolism
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms
nasopharynx carcinoma
nasopharynx tumor
Neoplastic Stem Cells
nonobese diabetic mouse
pathology
SCID mouse
Transplantation, Heterologous
tumor cell line
tumor marker
xenograft
Online Access:View Fulltext in Publisher
View in Scopus

Internet

View Fulltext in Publisher
View in Scopus

Similar Items