Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: Role of Gi protein, muscarinic receptors and TGR5

Bile acids are recognised as bioactive signalling molecules. While they are known to influence arrhythmia susceptibility in cholestasis, there is limited knowledge about the underlying mechanisms. To delineate mechanisms underlying fetal heart rhythm disturbances in cholestatic pregnancy, we used FR...

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Bibliographic Details
Main Authors:	Arunthavarajah, D. (Author), Diakonov, I. (Author), Goodwin, M. (Author), Gorelik, J. (Author), Ibrahim, E. (Author), McIlvride, S. (Author), Nikolova, V. (Author), Swift, T. (Author), Williamson, C. (Author)
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018
Subjects:	animal Animals bile acid Bile Acids and Salts cardiac muscle cell cholestasis Cholestasis disease model Disease Models, Animal female Female fetus heart rate G protein coupled receptor genetics Gpbar1 protein, mouse GTP-Binding Protein alpha Subunits, Gi-Go Heart Rate, Fetal inhibitory guanine nucleotide binding protein liver Liver metabolism Mice mouse muscarinic receptor Myocytes, Cardiac pathology physiology pregnancy Pregnancy Receptors, G-Protein-Coupled Receptors, Muscarinic signal transduction Signal Transduction
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Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: Role of Gi protein, muscarinic receptors and TGR5

Internet

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