Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: Role of Gi protein, muscarinic receptors and TGR5

Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: Role of Gi protein, muscarinic receptors and TGR5

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Bile acids are recognised as bioactive signalling molecules. While they are known to influence arrhythmia susceptibility in cholestasis, there is limited knowledge about the underlying mechanisms. To delineate mechanisms underlying fetal heart rhythm disturbances in cholestatic pregnancy, we used FR...

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Bibliographic Details
Main Authors: Arunthavarajah, D. (Author), Diakonov, I. (Author), Goodwin, M. (Author), Gorelik, J. (Author), Ibrahim, E. (Author), McIlvride, S. (Author), Nikolova, V. (Author), Swift, T. (Author), Williamson, C. (Author)
Format: Article
Language:English
Published: Nature Publishing Group 2018
Subjects:
animal
Animals
bile acid
Bile Acids and Salts
cardiac muscle cell
cholestasis
Cholestasis
disease model
Disease Models, Animal
female
Female
fetus heart rate
G protein coupled receptor
genetics
Gpbar1 protein, mouse
GTP-Binding Protein alpha Subunits, Gi-Go
Heart Rate, Fetal
inhibitory guanine nucleotide binding protein
liver
Liver
metabolism
Mice
mouse
muscarinic receptor
Myocytes, Cardiac
pathology
physiology
pregnancy
Pregnancy
Receptors, G-Protein-Coupled
Receptors, Muscarinic
signal transduction
Signal Transduction
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