Synthesis of diindolylmethane (DIM) bearing thiadiazole derivatives as a potent urease inhibitor

Synthesis of diindolylmethane (DIM) bearing thiadiazole derivatives as a potent urease inhibitor

The current study describes synthesis of diindolylmethane (DIM) derivatives based-thiadiazole as a new class of urease inhibitors. Diindolylmethane is natural product alkaloid reported to use in medicinal chemistry extensively. Diindolylmethane-based-thiadiazole analogs (1–18) were synthesized and c...

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Bibliographic Details
Main Authors: Ahmed, N. (Author), Anouar, E.H (Author), Ibrahim, M. (Author), Khan, A.A (Author), Rahim, F. (Author), Shah, S.A.A (Author), Taha, M. (Author), Zakari, Z.A (Author)
Format: Article
Language:English
Published: Nature Research, 2020
Subjects:
3,3'-diindolylmethane
biological model
chemical structure
chemistry
Chemistry Techniques, Synthetic
conformation
enzyme activation
Enzyme Activation
enzyme inhibitor
Enzyme Inhibitors
hydrogen bond
Hydrogen Bonding
indole derivative
Indoles
Models, Biological
Molecular Conformation
Molecular Structure
protein binding
Protein Binding
structure activity relation
Structure-Activity Relationship
synthesis
thiadiazole derivative
Thiadiazoles
urease
Urease
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