Valosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses

Valosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses

NOD2 polymorphisms may affect sensing of the bacterial muramyl dipeptide (MDP) and trigger perturbed inflammatory responses. Genetic screening of a patient with immunodeficiency and enteropathy revealed a rare homozygous missense mutation in the first CARD domain of NOD2 (ENST00000300589; c.160G >...

Full description

Bibliographic Details
Main Authors: Bufler, P. (Author), Conca, R. (Author), Fröhlich, T. (Author), Ghalandary, M. (Author), Hauck, F. (Author), Hollizeck, S. (Author), Klein, C. (Author), Koletzko, S. (Author), Kotlarz, D. (Author), Li, Y. (Author), Liu, Y. (Author), Magg, T. (Author), Muise, A.M (Author), Rohlfs, M. (Author), Schwerd, T. (Author), Snapper, S.B (Author), Uhlig, H.H (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
Acetylmuramyl-Alanyl-Isoglutamine
caspase recruitment domain protein 15
endoplasmic reticulum stress
Endoplasmic Reticulum Stress
genetics
human
Humans
interleukin 8
Interleukin-8
metabolism
n acetylmuramylalanyl dextro isoglutamine
NOD2 protein, human
Nod2 Signaling Adaptor Protein
valosin containing protein
Valosin Containing Protein
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items