Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

Novel therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. In addition, therapies that target unique vulnerabilities in the tumor microenvironment (TME) of EOC have largely been unrealized. One strategy to achieve selective drug delivery for EOC...

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Bibliographic Details
Main Authors: Back, J. (Author), Dzinic, S.H (Author), Gangjee, A. (Author), Gibson, H. (Author), Glassbrook, J. (Author), Hou, Z. (Author), Kim, S. (Author), Malysa, A. (Author), Matherly, L.H (Author), Morris, R.T (Author), O’Connor, C. (Author), Polin, L. (Author), Ravindra, M. (Author), Rubinsak, L. (Author), Schneider, M. (Author), Wallace-Povirk, A. (Author)
Format: Article
Language:English
Published: Nature Research 2022
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