Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

The non-classical class Ib molecule human leukocyte antigen E (HLA-E) has limited polymorphism and can bind HLA class Ia leader peptides (VL9). HLA-E-VL9 complexes interact with the natural killer (NK) cell receptors NKG2A-C/CD94 and regulate NK cell-mediated cytotoxicity. Here we report the isolati...

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Bibliographic Details
Main Authors: Alam, S.M (Author), Azoitei, M.L (Author), Barr, M. (Author), Borrow, P. (Author), Brackenridge, S. (Author), Cain, D.W (Author), Edwards, R.J (Author), Ferrari, G. (Author), Gillespie, G.M (Author), Harlos, K. (Author), Haynes, B.F (Author), Jones, E.Y (Author), Li, D. (Author), McMichael, A.J (Author), Mu, Z. (Author), Parks, R. (Author), Quastel, M. (Author), Rountree, W. (Author), Rozbesky, D. (Author), Saunders, K.O (Author), Scearce, R.M (Author), Swanson, O. (Author), Walters, L.C (Author), Wang, Y. (Author), Wiehe, K. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
animal
Animals
cytotoxicity
Cytotoxicity, Immunologic
genetics
Histocompatibility Antigens Class I
HLA antigen
HLA antigen class 1
HLA Antigens
HLA-E antigen
human
Humans
immunoglobulin
Immunoglobulins
Killer Cells, Natural
metabolism
Mice
mouse
natural killer cell
peptide
Peptides
Protein Sorting Signals
signal peptide
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