Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P....

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Main Authors: Amaratunga, C. (Author), Ashley, E.A (Author), Bozdech, Z. (Author), Chotivanich, K. (Author), Day, N.P.J (Author), Dhorda, M. (Author), Dondorp, A.M (Author), Faiz, A. (Author), Ginsburg, H. (Author), Hien, T.T (Author), Imwong, M. (Author), Jittamala, P. (Author), Kucharski, M. (Author), Lek, D. (Author), Lin, K. (Author), Mayxay, M. (Author), Miotto, O. (Author), Nayak, S. (Author), Newton, P.N (Author), Nguyen, H.C (Author), Nguyen, T.N.T (Author), Nosten, F. (Author), Peto, T.J (Author), Phyo, A.P (Author), Pukrittayakamee, S. (Author), Smithuis, F. (Author), Tripathi, J. (Author), Tripura, R. (Author), van der Pluijm, R.W (Author), von Seidlein, L. (Author), White, N.J (Author), Zhu, L. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
animal
Animals
antimalarial agent
Antimalarials
artemisinin
artemisinin derivative
Artemisinins
drug resistance
Drug Resistance
genetics
malaria falciparum
Malaria, Falciparum
parasite
Parasites
parasitology
Plasmodium falciparum
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