Protective effects of: Nigella sativa L. seed extract on lead induced neurotoxicity during development and early life in mouse models

Protective effects of: Nigella sativa L. seed extract on lead induced neurotoxicity during development and early life in mouse models

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Lead (Pb), a ubiquitous heavy metal and a known neurotoxicant, produces adverse effects on the brain via increased production of reactive oxygen species (ROS) and causes oxidative stress. In this study we examined the neuroprotective effects of the ethanolic extract of Nigella sativa L. seeds on Pb...

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Bibliographic Details
Main Authors: Ahmed, T. (Author), Butt, U.J (Author), Shah, S.A.A (Author), Zahid, S. (Author)
Format: Article
Language:English
Published: Royal Society of Chemistry 2018
Subjects:
amyloid precursor protein
animal experiment
animal model
animal tissue
Article
black cumin
brain cortex
brain development
controlled study
drug megadose
female
free radical scavenging assay
hippocampus
histology
lactation
lead poisoning
low drug dose
male
messenger RNA
mouse
neuroprotection
neurotoxicity
Nigella sativa extract
Nissl substance
nonhuman
oxidative stress
perinatal period
peroxiredoxin
plant seed
priority journal
protein expression
reverse transcription polymerase chain reaction
superoxide dismutase
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