Novel indole based hybrid oxadiazole scaffolds with: N -(substituted-phenyl)butanamides: Synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors

Novel indole based hybrid oxadiazole scaffolds with: N -(substituted-phenyl)butanamides: Synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors

In the study presented herein, 4-(1H-indol-3-yl)butanoic acid (1) was sequentially transformed in the first phase into ethyl 4-(1H-indol-3-yl)butanoate (2), 4-(1H-indol-3-yl)butanohydrazide (3) and 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazole-2-thiol (4) as a nucleophile. In the second phase, variou...

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Bibliographic Details
Main Authors: Abbasi, M.A (Author), Ali Shah, S.A (Author), Aziz-Ur-Rehman (Author), Hassan, M. (Author), Nazir, M. (Author), Raza, H. (Author), Seo, S.-Y (Author), Shahid, M. (Author), Siddiqui, S.Z (Author)
Format: Article
Language:English
Published: Royal Society of Chemistry 2018
Subjects:
Aniline
Binding energy
Chlorine compounds
Cytology
Enzymes
Inhibitory kinetics
Lineweaver-Burk plots
Molecules
Nucleophilic substitution reactions
Polycyclic aromatic hydrocarbons
Potent inhibitor
Structural confirmation
Substituted anilines
Substitution reactions
Therapeutic agents
Urease inhibitors
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