Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity

Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity

The epidermis is the outermost layer of the skin and the body's primary barrier to external pathogens; however, the early epidermal immune response remains to be mechanistically understood. We show that the chemokine CXCL14, produced by epidermal keratinocytes, exhibits robust circadian fluctua...

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Bibliographic Details
Main Authors: Akazawa, S. (Author), Doi, M. (Author), Egawa, G. (Author), Hara, T. (Author), Hata, R.-I (Author), Isa, T. (Author), Kabashima, K. (Author), Kono, Y. (Author), Murai, I. (Author), Nakamura, T. (Author), Nakao, R. (Author), Nishito, Y. (Author), Okamura, H. (Author), Saito, R. (Author), Santo, Y. (Author), Sugawa, M. (Author), Tanegashima, K. (Author), Tanioka, M. (Author), Tominaga, K. (Author), Tsujihana, K. (Author), Yamada, H. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
alpha chemokine
animal
Animals
bacterial skin disease
chemokine
Chemokines
Chemokines, CXC
circadian rhythms
CXCL14
CXCL14 protein, mouse
epidermis
Epidermis
Immunity, Innate
innate immunity
keratinocyte
Keratinocytes
mammal
Mammals
metabolism
Mice
mouse
Skin Diseases, Bacterial
Staphylococcus aureus
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