Methanol extract of Muntingia calabura leaves attenuates CCl4-induced liver injury: possible synergistic action of flavonoids and volatile bioactive compounds on endogenous defence system

Methanol extract of Muntingia calabura leaves attenuates CCl4-induced liver injury: possible synergistic action of flavonoids and volatile bioactive compounds on endogenous defence system

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Context:Muntingia calabura L. (Muntingiaceae) exerts antioxidant and anti-inflammatory activities, thus, it might be a good hepatoprotective agent. Objective: This study investigates the effect of methanol extract of M. calabura leaves (MMCL) on hepatic antioxidant and anti-inflammatory activities i...

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Bibliographic Details
Main Authors: Basir, R. (Author), Mahmood, N.D (Author), Omar, M.H (Author), Taher, M. (Author), Zakaria, Z.A (Author)
Format: Article
Language:English
Published: Taylor and Francis Ltd 2019
Subjects:
acetylcysteine
adverse drug reaction
alanine aminotransferase
alanine aminotransferase blood level
animal
animal cell
animal experiment
animal model
animal tissue
Animals
antiinflammatory activity
antioxidant
antioxidant activity
Antioxidants
Article
aspartate aminotransferase
aspartate aminotransferase blood level
carbon tetrachloride
Carbon Tetrachloride
catalase
Chemical and Drug Induced Liver Injury
chemistry
controlled study
cytokine
dimethyl sulfoxide
dose response
Dose-Response Relationship, Drug
drug activity
drug dose comparison
drug potentiation
ermanin I
ermanin II
ferulic acid
flavonoid
Flavonoids
gallic acid
GCMS
genistein
hepatoprotective activity
herbal medicine
histopathology
interleukin 1beta
interleukin 6
isolation and purification
kaempferide I
kaempferide II
liver enzyme
liver injury
liver level
liver protection
male
Male
Malvales
metabolism
methanol
Muntingia calabura
Muntingia calabura extract
Muntingiaceae
nitric oxide
nonhuman
oxidative stress markers
pathology
phenol derivative
phytochemical
Phytochemicals
phytochemistry
phytoconstituents
pinostrobin
plant extract
Plant Extracts
plant leaf
Plant Leaves
pro-inflammatory mediators
protein blood level
protocatechuic acid
qualitative analysis
quercetin
rat
Rats, Sprague-Dawley
Sprague Dawley rat
superoxide dismutase
toxic hepatitis
tumor necrosis factor
UHPLC-ESI
unclassified drug
unindexed drug
volatile organic compound
volatilization
Volatilization
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