Assessing Experimental Uncertainty in Defined Approaches: Borderline Ranges for in Chemico and in Vitro Skin Sensitization Methods Determined from Ring Trial Data

Assessing Experimental Uncertainty in Defined Approaches: Borderline Ranges for in Chemico and in Vitro Skin Sensitization Methods Determined from Ring Trial Data

Introduction: Prediction models of most toxicological assays translate continuous data to binary classifications ("positive"or "negative") using cutoff values. Mostly these cutoffs do not consider data variability. Some OECD test guidelines, however, provide a range close to the...

Full description

Bibliographic Details
Main Authors: Kolle, S.N (Author), Landsiedel, R. (Author), Mathea, M. (Author), Natsch, A. (Author)
Format: Article
Language:English
Published: Mary Ann Liebert Inc. 2021
Subjects:
Article
biological marker
borderline range
cell assay
cell differentiation
cell viability
cinnamaldehyde
cutoff
data analysis
decision tree
defined approach
direct peptide reactivity assay
follow up
high performance liquid chromatography
human
human cell
human cell line activation test
in vitro study
keratinosens
kinetic direct peptide reactivity assay
lusens
Organisation for Economic Co-operation and Development
oxidative stress
practice guideline
prediction
prediction model
skin sensitization
toxicology
uncertainty
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items