Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes
Adeno-Associated virus vectors are the most used delivery method for liver-directed gene editing. Still, they are associated with significant disadvantages that can compromise the safety and efficacy of therapies. Here, we investigate the effects of electroporating CRISPR-Cas9 as mRNA and ribonucleo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Mary Ann Liebert Inc.
2022
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| Online Access: | View Fulltext in Publisher |