Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes
Adeno-Associated virus vectors are the most used delivery method for liver-directed gene editing. Still, they are associated with significant disadvantages that can compromise the safety and efficacy of therapies. Here, we investigate the effects of electroporating CRISPR-Cas9 as mRNA and ribonucleo...
Main Authors: | Addlestone, E. (Author), Ates, I. (Author), Cottle, R.N (Author), Fernando, L. (Author), Lee, C.M (Author), Rathbone, T. (Author), Richards, V.P (Author) |
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Format: | Article |
Language: | English |
Published: |
Mary Ann Liebert Inc.
2022
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Online Access: | View Fulltext in Publisher |
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