Differential Potency of Venlafaxine, Paroxetine, and Atomoxetine to Inhibit Serotonin and Norepinephrine Reuptake in Patients With Major Depressive Disorder

Differential Potency of Venlafaxine, Paroxetine, and Atomoxetine to Inhibit Serotonin and Norepinephrine Reuptake in Patients With Major Depressive Disorder

BACKGROUND: Venlafaxine is a dual serotonin (5-HT) and norepinephrine reuptake inhibitor. The specific dose at which it begins to efficiently engage the norepinephrine transporter (NET) remained to be determined. Paroxetine is generally considered as a selective 5-HT reuptake inhibitor but exhibits...

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Bibliographic Details
Main Authors: Aldosary, F. (Author), Blier, P. (Author), James, J.S (Author), Norris, S. (Author), Ritchie, J.C (Author), Tremblay, P. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
antidepressant agent
Antidepressant doses
Antidepressive Agents, Second-Generation
atomoxetine
Atomoxetine Hydrochloride
blood pressure
cyclohexanol derivative
Cyclohexanols
Depressive Disorder, Major
human
Humans
major depression
noradrenalin
noradrenalin transporter
Norepinephrine
Norepinephrine Plasma Membrane Transport Proteins
paroxetine
Paroxetine
plasma levels
serotonin
Serotonin
serotonin levels
serotonin uptake inhibitor
Serotonin Uptake Inhibitors
tyramine
Tyramine
venlafaxine
Venlafaxine Hydrochloride
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