A deterministic model for non-monotone relationship between translation of upstream and downstream open reading frames

A deterministic model for non-monotone relationship between translation of upstream and downstream open reading frames

Totally asymmetric simple exclusion process (TASEP) modelling was shown to offer a parsimonious explanation for the experimentally confirmed ability of a single upstream open reading frames (uORFs) to upregulate downstream translation during the integrated stress response. As revealed by numerical s...

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Bibliographic Details
Main Authors: Andreev, D.E (Author), Baranov, P.V (Author), Milogorodskii, A. (Author), Rachinskii, D. (Author)
Format: Article
Language:English
Published: Oxford University Press 2021
Subjects:
Asymptotic of stationary solution
Asymptotics
Asymptotics of stationary solution
Deterministic modeling
Macromolecules
Modified tasep model
Mrna translation regulation
open reading frame
Open reading frame
Open Reading Frames
Ordinary differential equation model
Ordinary differential equation models
Ordinary differential equations
Stationary solutions
Stress resistance
Translation regulation
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