Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection

Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection

Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measur...

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Bibliographic Details
Main Authors: Ananworanich, J. (Author), Anderson, J. (Author), Buranapraditkun, S. (Author), Chomchey, N. (Author), Chottanapund, S. (Author), Colby, D.J (Author), David, C. (Author), de Souza, M. (Author), Douek, D.C (Author), Haase, A. (Author), Helgeson, E. (Author), Kroon, E. (Author), Manasnayakorn, S. (Author), Phanuphak, N. (Author), Pinyakorn, S. (Author), Prueksakaew, P. (Author), Reilly, C. (Author), Robb, M.L (Author), Sacdalan, C. (Author), Schacker, T.W (Author), Schuetz, A. (Author), Tovanabutra, S. (Author), Trichavaroj, R. (Author), Vasan, S. (Author), Zulk, J. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
acute HIV infection
Anti-Retroviral Agents
antiretroviral therapy
antiretrovirus agent
CD4+ T lymphocyte
CD4-Positive T-Lymphocytes
HIV Infections
HIV reservoir
human
Human immunodeficiency virus infection
Humans
in situ hybridization
lymph node
Lymph Nodes
lymphoid tissues
RNA
T lymphocyte
T-Lymphocytes
Viral Load
virus load
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