URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia

URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia

Systemic perturbations can drive a neuroimmune cascade after surgical trauma, including affecting the blood-brain barrier (BBB), activating microglia, and contributing to cognitive deficits such as delirium. Delirium superimposed on dementia (DSD) is a particularly debilitating complication that ren...

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Bibliographic Details
Main Authors: Chiang, W. (Author), Gelbard, H.A (Author), Li, H. (Author), Miller-Rhodes, P. (Author), Terrando, N. (Author), Velagapudi, R. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
blood-brain barrier
CVN-AD
delirium superimposed on dementia
leucine-rich repeat kinase type 2
microgliosis
mixed lineage kinase type 3
neuroinflammation
URMC-099
vascular cell adhesion molecule type 1
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