Kinetic and Dynamic Effects on Degradation of von Willebrand Factor

Kinetic and Dynamic Effects on Degradation of von Willebrand Factor

The loss of high molecular weight multimers (HMWM) of von Willebrand factor (vWF) in aortic stenosis (AS) and continuous-flow left ventricular assist devices (cf-LVADs) is believed to be associated with high turbulent blood shear. The objective of this study is to understand the degradation mechanis...

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Bibliographic Details
Main Authors: Bartoli, C.R (Author), Bohnenberger, K. (Author), Cysyk, J.P (Author), Jhun, C.-S (Author), Lukic, B. (Author), Newswanger, R. (Author), Rosenberg, G. (Author), Scheib, C.M (Author), Shen, C. (Author), Siedlecki, C. (Author), Weiss, W.J (Author), Xu, L. (Author), Yeager, E. (Author)
Format: Article
Language:English
Published: Lippincott Williams and Wilkins 2023
Subjects:
ADAMTS13
aortic stenosis
Aortic stenosis
Blood
blood shear
Blood shear
Blood vessels
Condition
Degradation
Diseases
Exposure-time
Glycoproteins
Heart-Assist Devices
High molecular weight
human
Humans
Kinetic effect
kinetics
Kinetics
Kinetics and dynamics
Laminar flow
left ventricular assist devices
Left ventricular assist devices
metabolism
molecular weight
Molecular Weight
Multimers
Reynolds number
Shear flow
turbulence
von Willebrand disease
von Willebrand Diseases
von Willebrand factor
von Willebrand Factor
Von Willebrand factor
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