Scanning ion conductance microscopy: A convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells

Scanning ion conductance microscopy: A convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells

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Cardiovascular diseases are complex pathologies that include alterations of various cell functions at the levels of intact tissue, single cells and subcellular signalling compartments. Conventional techniques to study these processes are extremely divergent and rely on a combination of individual me...

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Bibliographic Details
Main Authors: Chester, A.H (Author), El-Hamamsy, I. (Author), Gorelik, J. (Author), Harding, S.E (Author), Klenerman, D. (Author), Korchev, Y.E (Author), Lab, M.J (Author), Lyon, A.R (Author), Miragoli, M. (Author), Mitchell, J.A (Author), Moshkov, A. (Author), Nikolaev, V.O (Author), Novak, P. (Author), Potter, C.M.F (Author), Sheikh Abdul Kadir, S.H (Author), Shevchuk, A. (Author), Wright, P. (Author)
Format: Article
Language:English
Subjects:
Animals
aorta valve
Aorta, Thoracic
Aortic arch
atherosclerosis
beta 1 adrenergic receptor
beta 2 adrenergic receptor
beta adrenergic receptor
blood flow
blood flow velocity
blood vessel
blood viscosity
Cardiac myocytes
Cardiology
Cardiomyocyte contraction
Cardio-vascular disease
Cardiovascular Diseases
Cell functions
Cell orientation
Cell volume
Cells
Cellular contraction
Cellular levels
congestive cardiomyopathy
Conventional techniques
Cyclic adenosine
cyclic AMP
Diseases
Dynamic analysis
Electrophysiology
endothelium cell
Fetal monitoring
fluorescence resonance energy transfer
Functional parameters
Heart
heart disease
heart electrophysiology
Heart failure
heart function
heart hypertrophy
heart muscle cell
heart muscle contractility
heart valve
High resolution
human
Humans
hypertrophic obstructive cardiomyopathy
Intracellular calcium
Intracellular signalling
Ion channel
Ion conductance
Ions
Limited information
Membrane morphology
Membrane potentials
Membrane receptors
microscopy
Microscopy
Multimodal imaging
muscarinic M2 receptor
Myocytes, Cardiac
Nanometre resolution
Patch-clamp
Pathology
Receptors
review
Scanning
scanning ion conductance microscopy
Scanning ion conductance microscopy
Single cells
Single channels
Single parameter
Sub-cellular
Subcellular localizations
Therapeutic strategy
Tissue
Tissue levels
Vascular disease
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