Lifelong reductions of PKMζ in ventral hippocampus of nonhuman primates exposed to early-life adversity due to unpredictable maternal care

Lifelong reductions of PKMζ in ventral hippocampus of nonhuman primates exposed to early-life adversity due to unpredictable maternal care

Protein kinase Mζ (PKMζ) maintains long-term potentiation (LTP) and long-term memory through persistent increases in kinase expression. Early-life adversity is a precursor to adult mood and anxiety disorders, in part, through persistent disruption of emotional memory throughout life. Here we subject...

Full description

Bibliographic Details
Main Authors: Atkin, T. (Author), Coplan, J.D (Author), Fenton, A.A (Author), Fulton, S.L (Author), Hsieh, C. (Author), Norris, R. (Author), Sacktor, T.C (Author), Schoenfeld, E. (Author), Tsokas, P. (Author)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press 2021
Subjects:
adult
adult animal
Adverse Childhood Experiences
animal
Animals
article
controlled study
dentate gyrus
down regulation
female
foraging
hippocampal CA1 region
hippocampus
Hippocampus
histopathology
human
human experiment
human tissue
immunohistochemistry
long term potentiation
Long-Term Potentiation
Macaca
male
Male
maternal care
memory
metabolism
nonhuman
primate
Primates
protein expression
protein kinase C
Protein Kinase C
quantitative analysis
subiculum
ventral hippocampus
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items