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01622nam a2200313Ia 4500 |
| 001 |
10.1103-PhysRevResearch.4.L022008 |
| 008 |
220510s2022 CNT 000 0 und d |
| 020 |
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|a 26431564 (ISSN)
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| 245 |
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|a Dynamical systems theory of cellular reprogramming
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| 260 |
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|b American Physical Society
|c 2022
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.1103/PhysRevResearch.4.L022008
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|a In cellular reprogramming, almost all epigenetic memories of differentiated cells are erased by the overexpression of a few genes, resulting in regaining pluripotency, the potential for differentiation. Considering the interplay between oscillatory gene expression and slower epigenetic modifications, such reprogramming is perceived as an unintuitive, global attraction to the unstable manifold of a saddle, which represents pluripotency. The universality of this scheme is confirmed by the repressilator model and by gene regulatory networks that are randomly generated and extracted from embryonic stem cells. © 2022 authors. Published by the American Physical Society.
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|a Cell/B.E
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|a Cell/BE
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|a Cell-be
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|a Cellular reprogramming
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|a Differentiated cells
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|a Dynamical system theory
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|a Dynamical systems
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| 650 |
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|a Epigenetic memory
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| 650 |
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|a Gene expression
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| 650 |
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|a Genes expression
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|a Overexpressions
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| 650 |
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|a Pluripotency
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| 650 |
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|a Stem cells
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|a Hatakeyama, T.S.
|e author
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|a Kaneko, K.
|e author
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1 |
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|a Matsushita, Y.
|e author
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| 773 |
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|t Physical Review Research
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