Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance

Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance

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While age-related insulin resistance and hyperinsulinemia are usually considered to be secondary to changes in muscle, the liver also plays a key role in whole-body insulin handling and its role in age-related changes in insulin homeostasis is largely unknown. Here, we show that patent pores called...

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Bibliographic Details
Main Authors: Boyer, D. (Author), Catherine Li, S.-Y (Author), Cogger, V.C (Author), Cordwell, S.J (Author), Das, A. (Author), de Cabo, R. (Author), Fraser, R. (Author), Hilmer, S.N (Author), Le Couteur, D.G (Author), Mach, J. (Author), Mitchell, S.J (Author), Mohamad, M. (Author), Nines, D. (Author), Simpson, S.J (Author), Sinclair, D.A (Author), Solon-Biet, S.M (Author), Warren, A. (Author), White, M.Y (Author), Wu, L.E (Author)
Format: Article
Language:English
Published: Blackwell Publishing Ltd 2016
Subjects:
ageing
aging
animal experiment
Article
controlled study
endothelium
fenestrae
fenestrations
gluconeogenesis
glucose
glucose tolerance
homeostasis
hyperinsulinemia
insulin
insulin clearance
insulin resistance
lipoprotein metabolism
liver cell
liver sinusoid
microcirculation
nonhuman
poloxamer
priority journal
rat
senescence
signal transduction
ultrastructure
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