Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells

Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells

Background and Objective: Dental calculus is a mineralized deposit attached to the tooth surface. We have shown that cellular uptake of dental calculus triggers nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation, leading to the pr...

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Bibliographic Details
Main Authors: Hara, Y. (Author), Higuchi, K. (Author), Kaneko, T. (Author), Latz, E. (Author), Miyazaki, T. (Author), Montenegro Raudales, J.L (Author), Ozaki, Y. (Author), Ukai, T. (Author), Yoshimura, A. (Author), Ziauddin, S.M (Author)
Format: Article
Language:English
Published: Blackwell Munksgaard 2018
Subjects:
Amino Acid Chloromethyl Ketones
animal
Animals
apoptosis
Apoptosis
benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone
C57BL mouse
Carcinoma, Squamous Cell
Caspase 1
cell death
Cell Death
Cell Line, Tumor
cell membrane permeability
Cell Membrane Permeability
chemistry
cryopyrin
cytochalasin D
Cytochalasin D
dental calculus
Dental Calculus
drug effect
epithelial cells
Epithelial Cells
epithelium cell
human
Humans
inflammasome
inflammasomes
Inflammasomes
interleukin 1beta
interleukin 1beta converting enzyme
Interleukin-1beta
lactate dehydrogenase
L-Lactate Dehydrogenase
macrophage
Macrophages
metabolism
Mice
Mice, Inbred C57BL
mouse
NLR Family, Pyrin Domain-Containing 3 Protein
peptide chloromethyl ketone
squamous cell carcinoma
tooth calculus
tumor cell line
tumor necrosis factor
Tumor Necrosis Factor-alpha
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