Discovery of melanin-concentrating hormone receptor 1 in brown adipose tissue

Although extensive research on brown adipose tissue (BAT) has stimulated optimism in the battle against obesity and diabetes, BAT physiology and organ crosstalk are not fully understood. Besides BAT, melanin-concentrating hormone (MCH) and its receptor (MCHR1) play an important role in energy homeos...

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Main Authors:	Balber, T. (Author), Dumanic, M. (Author), Egger, G. (Author), Fürnsinn, C. (Author), Hacker, M. (Author), Herz, C.T (Author), Kiefer, F.W (Author), Klebermass, E.-M (Author), Kulterer, O.C (Author), Mitterhauser, M. (Author), Pallitsch, K. (Author), Philippe, C. (Author), Scherer, T. (Author), Scheuba, C. (Author), Spreitzer, H. (Author), Viernstein, H. (Author), Vraka, C. (Author), Wadsak, W. (Author), Zeilinger, M. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	3 [[3 [4 (3 acetamidophenyl) 1 piperidinyl]propyl]carbamoyl] 4 (3,4 difluorophenyl) 1,2,3,4 tetrahydro 6 (methoxymethyl) 2 oxo 5 pyrimidinecarboxylic acid methyl ester 5 [2 [[2 (3 chlorophenyl) 2 hydroxyethyl]amino]propyl] 1,3 benzodioxole 2,2 dicarboxylic acid adipocyte Adipose Tissue, Brown adult animal animal experiment animal model animal tissue Animals Article Bagg albino mouse beta 3 adrenergic receptor beta 3 adrenergic receptor stimulating agent binding affinity brown adipose tissue C57BL mouse cl316 243 controlled study energy balance fluorodeoxyglucose f 18 Fluorodeoxyglucose F18 gene expression hormone receptor human human cell human tissue Humans imaging in vitro study in vivo study ligand binding male Male MCHR1 melanin concentrating hormone receptor 1 melanin-concentrating hormone receptor messenger RNA metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL mouse nonhuman obesity PET positron emission tomography Positron-Emission Tomography protein function protein protein interaction rat Rats Rats, Sprague-Dawley real time reverse transcription polymerase chain reaction Receptors, Pituitary Hormone Sprague Dawley rat unclassified drug Western blotting
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Discovery of melanin-concentrating hormone receptor 1 in brown adipose tissue

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