The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma

The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma

Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged for years. Our previous studies found that the F-box protein SKP2 is overexpressed in osteosarcoma, acting as a proto-oncogene; p27Kip1 (p27) is an inhibitor of cyclin-dependent kinases and a downst...

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Bibliographic Details
Main Authors: Aldahamsheh, O. (Author), Borjihan, H. (Author), Ferrena, A. (Author), Geller, D.S (Author), Gorlick, R. (Author), Hoang, B.H (Author), Lo, Y. (Author), Schwartz, E.L (Author), Singh, S. (Author), Singla, A. (Author), Tingling, J. (Author), Viscarret, V. (Author), Wang, J. (Author), Yaguare, S. (Author), Yang, R. (Author), Zhao, H. (Author), Zheng, D. (Author), Zi, X. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
accumulation
alkaline phosphatase
animal
animal experiment
animal model
animal tissue
Animals
antiproliferative activity
apoptosis
Article
C57BL mouse
cancer growth
cancer stem cell
carcinogenesis
Carcinogenesis
caspase 3
CD133 antigen
cell culture
cell cycle arrest
cell proliferation
Cells, Cultured
controlled study
cyclin dependent kinase inhibitor 1B
Cyclin-Dependent Kinase Inhibitor p27
cycloheximide
gene expression
gene expression regulation
Gene Expression Regulation, Neoplastic
gene knockout
gene loss
gene mutation
genetically engineered mouse strain
genetics
human
human cell
Humans
immunofluorescence
immunohistochemistry
in vitro study
in vivo study
jaw tumor
knockout mouse
limb tumor
lung metastasis
lung nodule
male
messenger RNA
metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
missense mutation
mouse
nonhuman
osteocalcin
osteosarcoma
Osteosarcoma
overall survival
oxidative phosphorylation
p27
pathology
penetrance
pevonedistat
phosphorylation
primary culture
primary tumor
protein depletion
protein p27
protein p53
protein phosphorylation
protein protein interaction
Rb1 protein, mouse
retinoblastoma binding protein
Retinoblastoma Binding Proteins
retinoblastoma protein
RNA sequencing
S phase kinase associated protein
S phase kinase associated protein 2
SCFSKP2 inhibitors
S-Phase Kinase-Associated Proteins
stem cell factor receptor
transcription regulation
transgenic mouse
Trp53 protein, mouse
Tumor Suppressor Protein p53
tumor volume
Western blotting
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