Autoantibodies against the immunodominant sCha epitope discriminate the risk of sudden death in chronic Chagas cardiomyopathy

Autoantibodies against the immunodominant sCha epitope discriminate the risk of sudden death in chronic Chagas cardiomyopathy

In Chagas disease (ChD) caused by Trypanosoma cruzi, new biomarkers to predict chronic cardiac pathology are urgently needed. Previous studies in chagasic patients with mild symptomatology showed that antibodies against the immunodominant R3 epitope of sCha, a fragment of the human basic helix-loop-...

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Main Authors: Callejas-Hernández, F. (Author), Carrillo, I. (Author), Chorro-de-Villaceballos, M.A (Author), Fresno, M. (Author), Galán-Martínez, J. (Author), Gironès, N. (Author), Górgolas, M. (Author), Guhl, F. (Author), Herreros-Cabello, A. (Author), Isoler-Alcaráz, J. (Author), Lamsfus-Calle, A. (Author), López-Vélez, R. (Author), Marques, J. (Author), Maza, M.C (Author), Mendoza, I. (Author), Monge-Maillo, B. (Author), Moral-Salmoral, J.D (Author), Norman, F. (Author), Pérez-Ayala, A. (Author), Pérez-Molina, J.A (Author), Pérez-Tanoira, R. (Author), Poveda, C. (Author), Ramírez, J.D (Author), Rodríguez-Angulo, H.O (Author), Santi-Rocca, J. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
alanine scan
Antibodies, Protozoan
Autoantibodies
autoantibody
biological marker
Biomarkers
cardiomyopathy
Chagas
Chagas cardiomyopathy
Chagas Cardiomyopathy
Chagas disease
Chagas Disease
chronic disease
Chronic Disease
clinical trial
complication
cross reaction
Cross Reactions
Death, Sudden
disease predisposition
Disease Susceptibility
epitope
human
Humans
immunodominant epitope
Immunodominant Epitopes
immunology
metabolism
multicenter study
parasitology
prognosis
protozoon antibody
sudden death
Trypanosoma cruzi
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