Antitumor and antimigration effects of Salvia clandestina L. extract on osteosarcoma cells

Antitumor and antimigration effects of Salvia clandestina L. extract on osteosarcoma cells

Salvia clandestina L. is a wild perennial species present in the Salento area of Italy. Here, we examined the in vitro effects of an aqueous extract of S. clandestina L. on the MG-63 osteosarcoma cell line. The extract reduced osteosarcoma cell viability mainly by way of apoptosis, as we observed (1...

Full description

Bibliographic Details
Main Authors: De Bellis, L. (Author), Marsigliante, S. (Author), Muscella, A. (Author), Negro, C. (Author), Nutricati, E. (Author), Stefàno, E. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adezmapimod
anthra[1,9 cd]pyrazol 6(2h) one
antineoplastic activity
antineoplastic agent
Antineoplastic Agents, Phytogenic
apoptosis
Apoptosis
Article
biological model
Bone Neoplasms
bone tumor
cell cycle
Cell Cycle
cell cycle arrest
Cell Line, Tumor
cell migration
cell proliferation
Cell Proliferation
cell viability
chemistry
Chromatography, High Pressure Liquid
cisplatin
controlled study
cyclin dependent kinase inhibitor 1
cyclin dependent kinase inhibitor 1B
cytotoxicity
danshensu
dose response
Dose-Response Relationship, Drug
down regulation
drug effect
epithelial mesenchymal transition
Epithelial-Mesenchymal Transition
epithelial-to-mesenchymal transition
flow cytometry
gelatinase A
genetics
high performance liquid chromatography
human
human cell
Humans
in vitro study
Italy
MAPKs
matrix metalloproteinase
Matrix Metalloproteinases
matrix-assisted laser desorption-ionization mass spectrometry
messenger RNA
metabolism
MG-63 osteosarcoma
mitogen activated protein kinase
mitogen activated protein kinase 9
mitogen activated protein kinase p38
MMPs
Models, Biological
osteosarcoma
Osteosarcoma
osteosarcoma cell
phenolic compounds
plant extract
Plant Extracts
polyacrylamide gel electrophoresis
propidium iodide
protein Bax
protein expression
protein kinase B
protein p53
Salvia
Salvia clandestina
Salvia clandestina extract
Salvia clandestina L.
signal transduction
Signal Transduction
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
stress activated protein kinase 1
tumor cell line
unclassified drug
upregulation
Western blotting
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items