Antitumor and antimigration effects of Salvia clandestina L. extract on osteosarcoma cells

Antitumor and antimigration effects of Salvia clandestina L. extract on osteosarcoma cells

Salvia clandestina L. is a wild perennial species present in the Salento area of Italy. Here, we examined the in vitro effects of an aqueous extract of S. clandestina L. on the MG-63 osteosarcoma cell line. The extract reduced osteosarcoma cell viability mainly by way of apoptosis, as we observed (1...

Full description

Bibliographic Details
Main Authors:	De Bellis, L. (Author), Marsigliante, S. (Author), Muscella, A. (Author), Negro, C. (Author), Nutricati, E. (Author), Stefàno, E. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	adezmapimod anthra[1,9 cd]pyrazol 6(2h) one antineoplastic activity antineoplastic agent Antineoplastic Agents, Phytogenic apoptosis Apoptosis Article biological model Bone Neoplasms bone tumor cell cycle Cell Cycle cell cycle arrest Cell Line, Tumor cell migration cell proliferation Cell Proliferation cell viability chemistry Chromatography, High Pressure Liquid cisplatin controlled study cyclin dependent kinase inhibitor 1 cyclin dependent kinase inhibitor 1B cytotoxicity danshensu dose response Dose-Response Relationship, Drug down regulation drug effect epithelial mesenchymal transition Epithelial-Mesenchymal Transition epithelial-to-mesenchymal transition flow cytometry gelatinase A genetics high performance liquid chromatography human human cell Humans in vitro study Italy MAPKs matrix metalloproteinase Matrix Metalloproteinases matrix-assisted laser desorption-ionization mass spectrometry messenger RNA metabolism MG-63 osteosarcoma mitogen activated protein kinase mitogen activated protein kinase 9 mitogen activated protein kinase p38 MMPs Models, Biological osteosarcoma Osteosarcoma osteosarcoma cell phenolic compounds plant extract Plant Extracts polyacrylamide gel electrophoresis propidium iodide protein Bax protein expression protein kinase B protein p53 Salvia Salvia clandestina Salvia clandestina extract Salvia clandestina L. signal transduction Signal Transduction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization stress activated protein kinase 1 tumor cell line unclassified drug upregulation Western blotting
Online Access:	View Fulltext in Publisher

Similar Items

Protein kinase C signaling and cell cycle regulation
by: Adrian R Black, et al.
Published: (2013-01-01)

Cardamonin inhibits the growth of human osteosarcoma cells through activating P38 and JNK signaling pathway
by: Lulu Zhang, et al.
Published: (2021-02-01)

Mesenchymal stem cells decrease lung inflammation during sepsis, acting through inhibition of the MAPK pathway
by: Leonardo Pedrazza, et al.
Published: (2017-12-01)

Endothelin-1 Activates MAPKs and Modulates Cell Cycle Proteins in OKP Cells
by: Tzong-Shinn Chu, et al.
Published: (2007-01-01)

Expression and clinical significance of MMP-2, MVD, MEK-2 in endometriosis
by: Wei Zhang, et al.
Published: (2016-03-01)

p38 MAPK and the C2C12 cell cycle : in vitro and in silico investigations.
by: Driscoll, Scott Robert Ellery.
Published: (2014)

The Cell Wall Integrity Signaling Pathway and Its Involvement in Secondary Metabolite Production
by: Vito Valiante
Published: (2017-12-01)

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cells in vivo by altering MAPK and MMP signalling
by: Guohua Zhu, et al.
Published: (2020-01-01)

Albumin induces upregulation of matrix metalloproteinase-9 in astrocytes via MAPK and reactive oxygen species-dependent pathways
by: Ranaivo Hantamalala, et al.
Published: (2012-04-01)

Smads, p38 and ERK1/2 are involved in BMP9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells
by: Dao-jing Xu, et al.
Published: (2012-04-01)

Cadmium Toxicity on Arterioles Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats
by: Elbert L. Myles, et al.
Published: (2006-12-01)

The Solanum chacoense Fertilization-Related Kinase 3 (ScFRK3) is involved in male and female gametophyte development
by: Caroline Daigle, et al.
Published: (2019-05-01)

Targeting extracellular matrix remodeling in disease: Could resveratrol be a potential candidate?
by: Agarwal, P., et al.
Published: (2017)

Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells
by: Yan-fang Zhao, et al.
Published: (2013-08-01)

Prospect of Using ERK1/2 and р38 in Regeneration-Competent Cells of Nervous Tissue as a Drug Targets for Treating Alzheimer's Disease
by: Chayikovskyi, A.V, et al.
Published: (2023)

Focal adhesion kinase-regulated signaling events in human cancer
by: Fu Wei, et al.
Published: (2012-06-01)

Multisystemic Pediatric Langerhans cell histiocytosis: a comprehensive clinico-pathological and BRAF V600E mutation study at autopsy
by: Gargi Kapatia, et al.
Published: (2021-07-01)

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition – implications for the next generation of DC vaccines
by: Jason Adhikaree, et al.
Published: (2019-07-01)

Role of epidermal growth factor receptor (EGFR) and mitogen-activated protein kinases (MAPKs) signaling pathways in Zn-BC-AM photodynamic therapy-induced apoptosis of the well-differentiated nasopharyngeal carcinoma cell
by: Koon, Ho Kee
Published: (2009)

The Red Algae Compound 3-Bromo-4,5-dihydroxybenzaldehyde Protects Human Keratinocytes on Oxidative Stress-Related Molecules and Pathways Activated by UVB Irradiation
by: Mei Jing Piao, et al.
Published: (2017-08-01)

Dexamethasone Inhibits Interleukin-1β-Induced Matrix Metalloproteinase-9 Expression in Cochlear Cells
by: Sung-Il Nam, et al.
Published: (2014-09-01)

Pharmacological implications from the adhesion-induced signaling profiles in cultured human retinal pigment epithelial cells
by: Wen-Chuan Wu, et al.
Published: (2014-01-01)

Effects of Deoxynivalenol and Mycotoxin Adsorbent Agents on Mitogen-Activated Protein Kinase Signaling Pathways and Inflammation-Associated Gene Expression in Porcine Intestinal Epithelial Cells
by: Yu-Hsiang Yu, et al.
Published: (2021-04-01)

Dioscin Promotes Prostate Cancer Cell Apoptosis and Inhibits Cell Invasion by Increasing SHP1 Phosphorylation and Suppressing the Subsequent MAPK Signaling Pathway
by: Shuyun He, et al.
Published: (2020-07-01)

Ganoderan (GDN) Regulates The Growth, Motility And Apoptosis Of Non-Small Cell Lung Cancer Cells Through ERK Signaling Pathway In Vitro And In Vivo
by: Wang W, et al.
Published: (2019-10-01)

The MAPK Signaling Pathways as a Novel Way in Regulation and Treatment of Parasitic Diseases
by: Yumin Zhao, et al.
Published: (2019-01-01)

Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect
by: Che-Chung Yeh, et al.
Published: (2017-11-01)

Activation de la CDK4, clef de l'engagement du cycle cellulaire et carrefour des voies oncogéniques: évaluation de l'implication de la kinase activatrice des CDKs (CAK) et des phosphorylations de p21
by: Bisteau, Xavier
Published: (2013)

The role of MAP kinases in the regulation of mechanical load induced procollagen gene expression in cardiac fibroblasts
by: Papakrivopoulou, Eugenia Spyridoula
Published: (2001)

Targeting the MDSCs of Tumors In Situ With Inhibitors of the MAPK Signaling Pathway to Promote Tumor Regression
by: Jiayun Yu, et al.
Published: (2021-03-01)

Cell Polarity Protein Pals1-Associated Tight Junction Expression Is a Favorable Prognostic Marker in Clear Cell Renal Cell Carcinoma
by: Pingping Li, et al.
Published: (2020-08-01)

Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection
by: Yan B., et al.
Published: (2006-01-01)

<a name="home"></a>Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection
by: B. Yan, et al.
Published: (2006-02-01)

Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum
by: Wei Zhang, et al.
Published: (2019-01-01)

Delivery of Protein Kinase A by CRISPRMAX and Its Effects on Breast Cancer Stem-Like Properties
by: Jun-Nian Zhou, et al.
Published: (2021-12-01)

Effects of Homocysteine and Hyperglycemia on the Proliferation of Aortic Vascular Smooth Muscle Cells of Obese Type 2 Diabetes Rat
by: Hyung Joon Yoo, et al.
Published: (2017-06-01)

Norcantharidin Enhances High Concentrations of Fetal Bovine Serum-Induced Apoptosis in Human Mesangial Cells by Regulating the Mitogen-Activated Protein Kinase Signaling Pathway
by: Kun Ye, et al.
Published: (2019-10-01)

The MAPKKK CgMck1 Is Required for Cell Wall Integrity, Appressorium Development, and Pathogenicity in <i>Colletotrichum gloeosporioides</i>
by: Yu-Lan Fang, et al.
Published: (2018-11-01)

Lipopolysaccharide pretreatment increases protease-activated receptor-2 expression and monocyte chemoattractant protein-1 secretion in vascular endothelial cells
by: Hung-Hsing Chao, et al.
Published: (2017-11-01)

Crocetin suppresses the growth and migration in HCT-116 human colorectal cancer cells by activating the p-38 MAPK signaling pathway
by: Esmaeil Khajeh, et al.
Published: (2020-01-01)