Chemotherapy-induced oral mucositis and associated infections in a novel organotypic model

Chemotherapy-induced oral mucositis and associated infections in a novel organotypic model

Oral mucositis is a common side effect of cancer chemotherapy, with significant adverse impact on the delivery of anti-neoplastic treatment. There is a lack of consensus regarding the role of oral commensal microorganisms in the initiation or progression of mucositis because relevant experimental mo...

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Bibliographic Details
Main Authors: Bertolini, M. (Author), Diaz, P.I (Author), Dongari-Bagtzoglou, A. (Author), Peterson, D.E (Author), Sobue, T. (Author), Thompson, A. (Author)
Format: Article
Language:English
Published: Blackwell Publishing Ltd 2018
Subjects:
adherens junction
Adherens Junctions
adverse drug reaction
apoptosis
Apoptosis
Article
Bacteria
bacterial growth
bacterium
biofilm
Biofilms
cadherin
Cadherins
cancer chemotherapy
Candida
Candida albicans
cell line
Cell Line
cell migration assay
cell proliferation
Cell Proliferation
chemically induced
chemotherapy
commensal
cytokine
Cytokines
dissolution
dose response
Dose-Response Relationship, Drug
drug effect
drug therapy
Drug Therapy
Drug-Related Side Effects and Adverse Reactions
Epithelial Cells
epithelium cell
fibroblast
Fibroblasts
fluorouracil
Fluorouracil
Fungi
fungus
fungus growth
granulocyte macrophage colony stimulating factor
growth, development and aging
histopathology
HL-60 cell line
HL-60 Cells
human
human cell
Humans
in vitro study
injuries
intercellular space
interleukin 10
interleukin 1beta
interleukin 6
interleukin 8
leukocyte migration
metabolism
microbiology
molecular pathology
mouth flora
mucosa
Mucous Membrane
nonhuman
oral mucositis
pathogenicity
pathology
SCC-15 cell line
stomatitis
Stomatitis
Streptococcus
Streptococcus oralis
tumor necrosis factor
uvomorulin
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