Characterization and development of SAPP as a specific peptidic inhibitor that targets Porphyromonas gingivalis

Porphyromonas gingivalis is a keystone bacterium in the oral microbial communities that elicits a dysbiosis between the microbiota and the host. Therefore, inhibition of this organism in dental plaques has been one of the strategies for preventing and treating chronic periodontitis. We previously id...

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Bibliographic Details
Main Authors:	Chazin, W.J (Author), Chen, H. (Author), Ho, M.-H (Author), Kumar, P. (Author), Lamont, R.J (Author), Xie, H. (Author), Young, D.F (Author)
Format:	Article
Language:	English
Published:	Blackwell Publishing Ltd 2018
Subjects:	adhesin Adhesins, Bacterial Aggregatibacter actinomycetemcomitans alpha helix amino terminal sequence apoptosis argingipain, Porphyromonas gingivalis Article Bacterial Adhesion bacterial colonization bacterium adherence biofilm biofilms Biofilms cell damage cell membrane Cell Membrane cell surface circular dichroism comparative study controlled study Cysteine Endopeptidases cysteine proteinase cytotoxicity Dental Plaque drug effect ex vivo study fibroblast Fibroblasts fluorescence Fusobacterium nucleatum gene expression growth, development and aging human human cell Humans in vitro study keratinocyte lactate dehydrogenase liquid chromatography-mass spectrometry metabolism microbiology oral microbiology pathogenicity peptide Peptides periodontal disease periodontitis Periodontitis polymerase chain reaction porphyromonas Porphyromonas gingivalis protein secondary structure ribosome RNA RNA 23S RNA sequence streptococcal arca derived anti porphyromonas gingivalis peptide synthesis Tannerella forsythia tooth plaque Treponema denticola unclassified drug virulence Virulence
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Characterization and development of SAPP as a specific peptidic inhibitor that targets Porphyromonas gingivalis

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