High-speed quantitative optical imaging of absolute metabolism in the rat cortex

High-speed quantitative optical imaging of absolute metabolism in the rat cortex

Significance: Quantitative measures of blood flow and metabolism are essential for improved assessment of brain health and response to ischemic injury. Aim: We demonstrate a multimodal technique for measuring the cerebral metabolic rate of oxygen (CMRO2) in the rodent brain on an absolute scale (μM...

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Bibliographic Details
Main Authors: Akbari, Y. (Author), Bazrafkan, A. (Author), Choi, B. (Author), Crouzet, C. (Author), Maki, N. (Author), Torabzadeh, M. (Author), Tromberg, B.J (Author), Wilson, R.H (Author)
Format: Article
Language:English
Published: SPIE 2021
Subjects:
absorption
animal experiment
animal model
arterial gas
arterial pressure
Article
bicarbonate
Blood
Blood flow
blood pressure measurement
Brain
brain blood flow
brain cortex
brain ischemia
Brain ischemia
brain metabolism
Brain metabolism
brain perfusion
breathing rate
cardiac arrest
Cardiac arrest
cerebral blood flow
Cerebral blood flow
cerebral metabolic rate of oxygen
Cerebral metabolic rate of oxygen
controlled study
diffuse optical imaging
Diffuse optical imaging
electrocorticography
epinephrine
fluorescence imaging
Frequency domain analysis
heart arrest
hemicraniectomy
hemodynamics
Hemodynamics
hemoglobin
hemoglobin determination
High Speed
isoflurane
laser speckle imaging
Magnetic resonance
male
mathematical model
Metabolic rates
Metabolism
Monte Carlo method
nonhuman
nuclear magnetic resonance
Optical image storage
oxygen
Oxygen
partial volume (imaging)
positron emission tomography
Positron emission tomography
rat
Rats
resuscitation
return of spontaneous circulation
spatial frequency domain imaging
Speckle
Tissue
tissue oxygenation
vecuronium
Zero flow
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