Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study

Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study

Amphotericin B, an antifungal drug with a long history of use, forms fungicidal ion-permeable channels across cell membranes. Using solid-state nuclear magnetic resonance spectroscopy and molecular dynamics simulations, we experimentally elucidated the three-dimensional structure of the molecular as...

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Bibliographic Details
Main Authors: Dixit, M. (Author), Funahashi, K. (Author), Hanashima, S. (Author), Matsumori, N. (Author), Matsuoka, S. (Author), Murata, M. (Author), Nakagawa, Y. (Author), Oishi, T. (Author), Seo, S. (Author), Shinoda, W. (Author), Suzuki, T. (Author), Tsuchikawa, H. (Author), Umegawa, Y. (Author), Yamamoto, T. (Author)
Format: Article
Language:English
Published: American Association for the Advancement of Science 2022
Subjects:
Alcohols
Amphotericin B
Antifungal drugs
Cytology
Dynamic studies
Dynamics simulation
History of use
Ion channel
Ions
Molecular dynamics
Molecule ions
Molecules
Nuclear magnetic resonance spectroscopy
Permeable channels
Solid-state nuclear magnetic resonance spectroscopy
Three-dimensional structure
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