Open-label study of absorption and clearance of 1% voriconazole eye drops

Open-label study of absorption and clearance of 1% voriconazole eye drops

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Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in...

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Bibliographic Details
Main Authors: Al-Badriyeh, D. (Author), Chan, E. (Author), Davies, G.E (Author), Fullinfaw, R.O (Author), Jhanji, V. (Author), Kong, D.C.M (Author), Leung, L. (Author), Neoh, C.F (Author), Stewart, K. (Author), Vajpayee, R.B (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2016
Subjects:
adult
Adult
aged
Aged
Aged, 80 and over
antifungal agent
Antifungal Agents
aqueous humor
Aqueous Humor
Article
cataract extraction
Cataract Extraction
clinical article
clinical trial
drug absorption
drug clearance
drug effects
drug elimination
drug half life
elective surgery
elimination half-life
elimination rate constant
eye drops
female
Female
high performance liquid chromatography
human
Humans
in vitro study
infection prevention
keratomycosis
male
Male
middle aged
Middle Aged
minimum inhibitory concentration
open study
Ophthalmic Solutions
paracentesis
postoperative infection
priority journal
very elderly
voriconazole
Voriconazole
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