Prediction of improved antimalarial chemoprevention with weekly dosing of dihydroartemisinin-piperaquine

Prediction of improved antimalarial chemoprevention with weekly dosing of dihydroartemisinin-piperaquine

Intermittent preventive treatment (IPT) is used to reduce malaria morbidity and mortality, especially in vulnerable groups such as children and pregnant women. IPT with the fixed dose combination of piperaquine (PQ) and dihydroartemisinin (DHA) is being evaluated as a potential mass treatment to con...

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Bibliographic Details
Main Authors: Bergstrand, M. (Author), Karlsson, M.O (Author), Nosten, F. (Author), Permala, J. (Author), Tarning, J. (Author), White, N.J (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2017
Subjects:
antimalarial agent
Antimalarials
artemisinin derivative
Artemisinins
Article
Chemoprevention
chemoprophylaxis
combination drug therapy
computer simulation
Computer Simulation
dihydroartemisinin
Dihydroartemisinin-piperaquine
drug administration
Drug Administration Schedule
drug concentration
Drug Therapy, Combination
human
Humans
incidence
IPT
malaria
Malaria
malaria control
malaria falciparum
Malaria, Falciparum
maximum plasma concentration
Nonadherence
patient compliance
Pharmacodynamics
Pharmacokinetics
piperaquine
power analysis
prediction
priority journal
procedures
quinoline derivative
Quinolines
steady state
treatment outcome
Treatment Outcome
Weekly dosing
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