Bacterial cell enlargement requires control of cell wall stiffness mediated by peptidoglycan hydrolases

Bacterial cell enlargement requires control of cell wall stiffness mediated by peptidoglycan hydrolases

Most bacterial cells are enclosed in a single macromolecule of the cell wall polymer, peptidoglycan, which is required for shape determination and maintenance of viability, while peptidoglycan biosynthesis is an important antibiotic target. It is hypothesized that cellular enlargement requires regio...

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Bibliographic Details
Main Authors: Bailey, R.G (Author), Foster, S.J (Author), Hayhurst, E.J (Author), Hobbs, J.K (Author), Horsburgh, M. (Author), Mesnage, S. (Author), Mohamad, S.A.S (Author), Salamaga, B. (Author), Turner, R.D (Author), Wheeler, R. (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2015
Subjects:
Article
bacterial cell
bacterial cell wall
beta n acetylhexosaminidase
biomechanics
Biophysical Phenomena
biophysics
cell enlargement
Cell Enlargement
cell structure
cell surface
cell wall
Cell Wall
controlled study
enzyme activity
enzymology
gene inactivation
Gene Knockout Techniques
genetics
glucosaminidase
Hexosaminidases
metabolism
nonhuman
peptidoglycan
Peptidoglycan
peptidoglycan hydrolase
physiology
priority journal
protein Atl
protein SagB
protein ScaH
protein structure
rigidity
Staphylococcus aureus
transcription factor SAGA
unclassified drug
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