Genomic features associated with the degree of phenotypic resistance to carbapenems in carbapenem-resistant klebsiella pneumoniae

Genomic features associated with the degree of phenotypic resistance to carbapenems in carbapenem-resistant klebsiella pneumoniae

Carbapenem-resistant Klebsiella pneumoniae strains cause severe infections that are difficult to treat. The production of carbapenemases such as the K. pneumoniae carbapenemase (KPC) is a common mechanism by which these strains resist killing by the carbapenems. However, the degree of phenotypic car...

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Bibliographic Details
Main Authors: Bulman, Z.P (Author), Hauser, A.R (Author), Krapp, F. (Author), Murphy, K.R (Author), Ozer, E.A (Author), Pincus, N.B (Author), Qi, C. (Author), Wenzler, E. (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2021
Subjects:
allele
Antibiotic resistance
Article
bacterial gene
bacterium isolate
beta lactamase KPC
beta lactamase KPC 3
blood culture
carbapenem
Carbapenem
carbapenem resistance
carbapenem resistant Klebsiella pneumoniae
cell surface display
epsilometer test
ertapenem
extended spectrum beta lactamase
gene dosage
gene expression
gene identification
gene insertion sequence
gene locus
gene mutation
gene sequence
genetic association
genotype
hydrolase
imipenem
Klebsiella pneumoniae
Machine learning
meropenem
minimum inhibitory concentration
nested cross validation
nonhuman
nucleic acid base substitution
ompk35 gene
ompk36 gene
ompk37 gene
phenotypic variation
phylogenetic tree
porin
predictive value
promoter region
respiratory system
sample size
single nucleotide polymorphism
stop codon
support vector machine
transposon
unclassified drug
urine culture
whole genome sequencing
Whole-genome sequencing
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