Inactivation of nitrite-dependent nitric oxide biosynthesis is responsible for overlapped antibiotic resistance between naturally and artificially evolved pseudomonas aeruginosa

Inactivation of nitrite-dependent nitric oxide biosynthesis is responsible for overlapped antibiotic resistance between naturally and artificially evolved pseudomonas aeruginosa

Metabolic flexibility of Pseudomonas aeruginosa could lead to new strategies to combat bacterial infection. The present study used gas chromatographymass spectrometry (GC-MS)-based metabolomics to investigate global metabolism in naturally and artificially evolved strains with cefoperazone-sulbactam...

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Bibliographic Details
Main Authors: Chen, Z.-G (Author), Feng, D.-Y (Author), Kuang, S.-F (Author), Li, H. (Author), Liang, Z.-Z (Author), Peng, X.-X (Author), Xiang, J.-J (Author), Zhang, T. (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2021
Subjects:
antibiotic resistance
Antibiotic resistance
arginine
Article
bacterial strain
biosynthesis
cefoperazone plus sulbactam
Cefoperazone-sulbactam resistance
cephalosporin resistance
controlled study
electron
Fumarate
fumaric acid
mass fragmentography
metabolite
metabolome
metabolomics
Metabolomics
NADH
nicotinamide adenine dinucleotide
nitrate
Nitrate
nitric oxide
Nitric oxide
nitrite
Nitrite
nitroprusside sodium
nonhuman
oxidation
Pseudomonas aeruginosa
pyruvic acid
reduced nicotinamide adenine dinucleotide
Sodium nitroprusside
ubiquinol cytochrome c reductase
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