Novel drivers of virulence in clostridioides difficile identified via context-specific metabolic network analysis

Novel drivers of virulence in clostridioides difficile identified via context-specific metabolic network analysis

The pathogen Clostridioides difficile causes toxin-mediated diarrhea and is the leading cause of hospital-acquired infection in the United States. Due to growing antibiotic resistance and recurrent infection, targeting C. difficile metabolism presents a new approach to combat this infection. Genome-...

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Bibliographic Details
Main Authors: Dickenson, M.E (Author), Garrett, E.M (Author), Jenior, M.L (Author), Leslie, J.L (Author), Papin, J.A (Author), Petri, W.A., Jr (Author), Powers, D.A (Author), Tamayo, R. (Author), Walker, K.A (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2021
Subjects:
Article
bacterial growth
bacterial metabolism
bacterial virulence
bacterium identification
biofilm
carbohydrate
carbon
carbon source
Clostridioides difficile
controlled study
cytidine
gene deletion
in vitro study
in vivo study
Metabolic modeling
n acetylneuraminic acid
network analysis
nonhuman
pentose phosphate
pentose phosphate cycle
phase variation
predictive value
sporogenesis
transcriptome
Transcriptomics
virulence factor
Virulence factors
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