Higher trimethylamine-n-oxide plasma levels with increasing age are mediated by diet and trimethylamine-forming bacteria

Higher trimethylamine-n-oxide plasma levels with increasing age are mediated by diet and trimethylamine-forming bacteria

The gut microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) is linked to an increased risk for cardiovascular diseases. Trimethylamine (TMA), which is subsequently oxidized to TMAO in the liver, is formed by intestinal bacteria via distinct biochemical routes from dietary precursors that a...

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Bibliographic Details
Main Authors: Bardenhorst, S.K (Author), Brönstrup, M. (Author), Dörr, M. (Author), Frost, F. (Author), Karch, A. (Author), Lerch, M.M (Author), Mayerle, J. (Author), Pieper, D.H (Author), Rath, S. (Author), Rox, K. (Author), Schminke, U. (Author), Vital, M. (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2021
Subjects:
age
aged
Aging
Article
blood level
Cardiovascular disease
carotid intima-media thickness
cohort analysis
controlled study
Diet
female
gene targeting
human
intestine flora
major clinical study
male
meat consumption
metabolite
metabolomics
Microbiota
population research
prediction
trimethylamine
Trimethylamine
trimethylamine oxide
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