A genetic trap in yeast for inhibitors of SARS-CoV-2 main protease

A genetic trap in yeast for inhibitors of SARS-CoV-2 main protease

The ongoing COVID-19 pandemic urges searches for antiviral agents that can block infection or ameliorate its symptoms. Using dissimilar search strategies for new antivirals will improve our overall chances of finding effective treatments. Here, we have established an experimental platform for screen...

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Bibliographic Details
Main Authors: Alalam, H. (Author), Bourgard, C. (Author), Grøtli, M. (Author), King, R.D (Author), Sigurdardóttir, S. (Author), Sunnerhagen, P. (Author), Tiukova, I. (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2021
Subjects:
amino acid
amino acid sequence
anti-SARS-CoV-2 agent
Antiviral agents
Article
boceprevir
cell survival
codon
concentration (parameter)
controlled study
coronavirus 3C protease
coronavirus proteinase inhibitor
COVID-19
drug design
drug screening
efonidipine
fungal strain
fusion protein
gc 376
genetic background
genetic engineering
Genetic engineering
genetic selection
Genetic selection system
genetic strain
glycyrrhizic acid
lercanidipine
mazef fusion protein
MazF toxin
nonhuman
promoter region
proteinase inhibition
Saccharomyces cerevisiae
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Small molecules
unclassified drug
virostatic activity
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