Gut metabolites are more predictive of disease and cohoused states than gut bacterial features in a polycystic ovary syndrome-like mouse model

Gut metabolites are more predictive of disease and cohoused states than gut bacterial features in a polycystic ovary syndrome-like mouse model

Polycystic ovary syndrome (PCOS) impacts ;10% of reproductive-aged women worldwide. In addition to infertility, women with PCOS suffer from metabolic dysregulation which increases their risk of developing type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease. Studies have sho...

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Bibliographic Details
Main Authors: Benson, B. (Author), Ho, B. (Author), Kelley, S.T (Author), Mason, C.N (Author), Quinn, R.A (Author), Ryback, D. (Author), Thackray, V.G (Author), Torres, P.J (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2021
Subjects:
amplicon
animal experiment
animal housing
animal model
Article
bacterial strain
bile acid
Bile acids
bioinformatics
Bioinformatics
controlled study
coprophagy
female
Gut microbiome
intestine
intestine flora
letrozole
Longitudinal
metabolism
metabolite
metabolomics
Metabolomics
metagenomics
Metagenomics
microbial diversity
mouse
mouse model
Mouse model
multiomics
Multiomics
nonhuman
ovary polycystic disease
phenotype
placebo
precipitation
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