The Extracellular Milieu of Toxoplasma's Lytic Cycle Drives Lab Adaptation, Primarily by Transcriptional Reprogramming

The Extracellular Milieu of Toxoplasma's Lytic Cycle Drives Lab Adaptation, Primarily by Transcriptional Reprogramming

Evolve and resequencing (E&R) was applied to lab adaptation of Toxoplasma gondii for over 1,500 generations with the goal of mapping host-independent in vitro virulence traits. Phenotypic assessments of steps across the lytic cycle revealed that only traits needed in the extracellular milieu evo...

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Bibliographic Details
Main Authors: Farrell, A. (Author), Gubbels, M.-J (Author), Lou, J. (Author), Marth, G.T (Author), Murphy, C.Q (Author), Primo, V.A (Author), Rezvani, Y. (Author), Vajdi, A. (Author), Zarringhalam, K. (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2021
Subjects:
Evolve and resequencing
Experimental evolution
Genotype-phenotype correlation
Lab adaptation
Regression analysis
Serial passaging
Toxoplasma
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