Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccharide vaccine on pneumococcal colonisation using the experimental human pneumococcal challenge model in healthy adults (PREVENTING PNEUMO 2)

Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccharide vaccine on pneumococcal colonisation using the experimental human pneumococcal challenge model in healthy adults (PREVENTING PNEUMO 2)

INTRODUCTION: Despite widely available vaccinations, Streptococcus pneumoniae (SPN) remains a major cause of morbidity and mortality worldwide, causing community-acquired pneumonia, meningitis, otitis media, sinusitis and bacteraemia. Here, we summarise an ethically approved protocol for a double-bl...

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Main Authors: Anderson, A.S (Author), Begier, E. (Author), Chen, T. (Author), Collins, A. (Author), Davies, K. (Author), Ferreira, D.M (Author), Gessner, B.D (Author), Gordon, S.B (Author), Hyder-Wright, A. (Author), Liatsikos, K. (Author), Mitsi, E. (Author), Myerscough, C. (Author), Pan, K. (Author), PNEUMO 2 study group (Author), Pojar, S. (Author), Quinn, A. (Author), Reine, J. (Author), Robinson, R.E (Author), Solorzano, C. (Author), Theilacker, C. (Author), Urban, B. (Author), Wang, D. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
Epidemiology
Immunology
PREVENTIVE MEDICINE
Public health
Respiratory infections
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