Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

INTRODUCTION: Motor neuron disease (MND) is a rapidly fatal neurodegenerative disease. Despite decades of research and clinical trials there remains no cure and only one globally approved drug, riluzole, which prolongs survival by 2-3 months. Recent improved mechanistic understanding of MND heralds...

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Main Authors: Chandran, S. (Author), Chataway, J. (Author), Colville, S. (Author), Dakin, R.S (Author), Elliott, E. (Author), Gregory, J.M (Author), Macleod, M.R (Author), Mehta, A.R (Author), Newton, J. (Author), Pal, S. (Author), Parker, R.A (Author), Parmar, M.K.B (Author), Stallard, N. (Author), Stavrou, M. (Author), Steven, M. (Author), Swingler, R.J (Author), Weir, C.J (Author), Williamson, J. (Author), Wong, C. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
Clinical trials
Motor neurone disease
Neurology
STATISTICS & RESEARCH METHODS
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