PAX-D: study protocol for a randomised placebo-controlled trial evaluating the efficacy and mechanism of pramipexole as add-on treatment for people with treatment resistant depression

PAX-D: study protocol for a randomised placebo-controlled trial evaluating the efficacy and mechanism of pramipexole as add-on treatment for people with treatment resistant depression

INTRODUCTION: Clinical depression is usually treated in primary care with psychological therapies and antidepressant medication. However, when patients do not respond to at least two or more antidepressants within a depressive episode, they are considered to have treatment resistant depression (TRD)...

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Main Authors: Attenburrow, M.-J (Author), Au-Yeung, S.K (Author), Bogacz, R. (Author), Browning, M. (Author), Chan, F. (Author), Cipriani, A. (Author), Cleare, A. (Author), Cowen, P. (Author), Edwards, C. (Author), Evans, J. (Author), Geddes, J. (Author), Griffiths, J. (Author), Harmer, C.J (Author), Harrison, P.J (Author), Kessler, D. (Author), Lewis, G. (Author), Rendell, J. (Author), Roberts, S. (Author), Shanyinde, M. (Author), Simon, J. (Author), Singh, I. (Author), Watson, S. (Author), Yu, L.-M (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
adult psychiatry
depression & mood disorders
psychiatry
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